The Indian-American physician's acclaimed book on cancer, The Emperor of All Maladies: A Biography of Cancer, won the prestigious award.
The prize carries a $10,000 award.
Mukherjee's book was also listed in "The 10 Best Books of 2010" byThe New York Times and the "Top 10 Non-fiction Books" by theTime magazine. He is also listed on Time magazine's "100 Most Influential People" list this year.
Mukherjee, 40, who is an assistant professor of medicine at Columbia University, grew up in the city's Safdarjung Enclave and studied at St Columba's School before training as a cellular biologist in Oxford as a Rhodes scholar. His first book is a runaway success.
In his book, Mukherjee has recounted centuries of discoveries, setbacks, victories and deaths, told through the "eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out war against cancer".
An award-winning science writer, Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective and a biographer's passion.
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